Publications
Developmentally regulated long and short isoforms of MLLT3 balance human hematopoietic stem cell fate decisions.
Vavilina A, Calvanese V, Gu Y, Ma F, Quinones Valdez G, Fares I, Colombo G, Aguade Gorgorio J, Capellera-Garcia S, Nadel B, Wang Y, Nance K, Andrews A, Goodridge H, Seet C, Crooks G, Pellegrini M, Xiao G, Schenke-Layland K, Mikkola HKA. In revision
Multilineage engraftment of induced hematopoietic stem cells (iHSCs) differentiated from human pluripotent stem cells.
Ng ES. Li JY, GSarila G, HaEdirisinghe H, Saxena R, Sun S, Bruveris FF, Labonne T, Motazedian A, Calvanese V, Capellera-Garcia S, Ma F, Nim H, Ramialison M, Mikkola HKA, Stanley EG, Elefanty AG. Resubmitted
MYCT1 controls environmental sensing in human hematopoietic stem cells.
Aguadé-Gorgorió J, YaJami-Alahmadi Y, Calvanese V, Kardouh M, Fares I, Johnson H, Rezek V, Ma F, Magnusson M, Wang Y, Shin J, Nance K, Goodridge H, Liebscher S, Schenke-Layland K, Crooks G, Wohlschlegel J, Mikkola HKA. Provisionally accepted
2023
The Genesis of Human Hematopoietic Stem Cells.
Calvanese V and Mikkola HKA. Invited review, Blood 2023, 142 (6): 519–532. 2023.
https://doi.org/10.1182/blood.2022017934
2022
Decoding human hematopoietic stem cell self-renewal.
Fares I, Calvanese V, Mikkola HKA. Curr Stem Cell Rep (April 18, 2022). Invited review
https://doi.org/10.1007/s40778-022-00209-w
Mapping human haematopoietic stem cells from haemogenic endothelium to birth.
Calvanese V*, Capellera-Garcia S*, Ma F*, Fares I, Liebscher S, Ng E, Ekstrand S, Aguadé-Gorgorió J, Vavilina A, Lefaudeux D, Nadel B, Li JY, Wang Y, Lee LK, Ardehali R, Iruela-Arispe L, Pellegrini M, Stanely E, Elefanty A, Schenke-Layland K, Mikkola HKA. Nature, 2022 Apr;604(7906):534-540. doi: 10.1038/s41586-022-04571-x. Epub 2022 Apr 13.PMID: 35418685.
https://pubmed.ncbi.nlm.nih.gov/35418685/
Yolk sac steps up to the plate.
Mikkola HKA.J Exp Med. 2022 Mar 7;219(3):e20212315. doi: 10.1084/jem.20212315. Epub 2022 Feb 24.PMID: 35201267. Invited preview.
https://pubmed.ncbi.nlm.nih.gov/35201267/
2020
Nidogen-1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration.
Zbinden A, Layland SL, Urbanczyk M, Carvajal Berrio DA, Marzi J, Zauner M, Hammerschmidt A, Brauchle EM, Sudrow K, Fink S, Templin M, Liebscher S, Klein G, Deb A, Duffy GP, Crooks GM, Eble JA, Mikkola HKA, Nsair A, Seifert M, Schenke-Layland K. Advanced Science. 2020 Dec 21;8(4):2002500. doi: 10.1002/advs.202002500.eCollection 2021 Feb
https://pubmed.ncbi.nlm.nih.gov/33643791/
VEGF-C Protects the Integrity of Bone Marrow Perivascular Niche.
Fang S, Chen S, Nurmi H, Leppänen V-M, Jeltsch M, Scadden D, Silberstein L, Mikkola HKA*, Alitalo K*. Blood, Blood. 2020 Oct 15;136(16):1871-1883. Doi10.1182/blood.2020005699.PMID: 32842144 *co-corresponding authors
https://pubmed.ncbi.nlm.nih.gov/32842144/
2019
MLLT3 governs human hematopoietic stem cell self-renewal and engraftment.
Calvanese V*, Nguyen AT, Bolan T, Vavilina A, Su T, Lee l, Wang Y, Lay FD, Magnusson M, Crooks GM, Kurdistani SK, Mikkola HKA*. Nature 2019. Dec;576(7786):281-286. Epub 2019 Nov 27. *co-corresponding authors
https://pubmed.ncbi.nlm.nih.gov/31776511/
2018
Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes.
Ferguson GB, Van Handel B, Bay M, Fiziev P, Org T, Lee S, Shkhyan R, Banks NW, Scheinberg M, Wu L, Saitta B, Elphingstone J, Larson AN, Riester SM, Pyle AD, Bernthal NM, Mikkola HK, Ernst J, van Wijnen AJ, Bonaguidi M, Evseenko D. Nat Commun. 2018 Sep 7;9(1):3634. doi: 10.1038/s41467-018-05573-y PMID:30194383
https://www.ncbi.nlm.nih.gov/pubmed/30194383/
Protagonist or antagonist? The complex roles of retinoids in the regulation of hematopoietic stem cells and their specification from pluripotent stem cells.
Grace CS, Mikkola HKA, Dou DR, Calvanese V, Ronn RE, Purton LE. Exp Hematol. 2018 Jul 4. pii: S0301-472X(18)30620-9. doi: 10.1016/j.exphem.2018.06.287. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/pubmed/29981365/
Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis.
Park S, Ranjbarvazirj S, Lay FD, Zhao P, Miller MJ, Dhaliwal JS, Huertas-Vazquez A, Wu X, Qiao R, Soffer JM, Mikkola HKA, Lusis AJ, Ardehali R. Circulation. 2018 Jun 27. pii: CIRCULATIONA.118.035420. doi: 10.1161/CIRCULATIONAHA.118.035420. [Epub]
https://pubmed.ncbi.nlm.nih.gov/29950403/
Analysis of cardiomyocyte clonal expansion during mouse heart development and injury.
Sereti KI, Nguyen NB, Kamran P, Zhao P, Ranjbarvaziri S, Park S, Sabri S, Engel JL, Sung K, Kulkarni RP, Ding Y, Hsiai TK, Plath K, Ernst J, Sahoo D, Mikkola HKA, Iruela-Arispe ML, Ardehali R. Nat Commun. 2018 Feb 21;9(1):754. doi: 10.1038/s41467-018-02891-z.
https://pubmed.ncbi.nlm.nih.gov/29467410/
2017
Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration.
Komorowska K, Doyle A, Wahlestedt M, Subramaniam A, Debnath S, Chen J, Soneji S, Van Handel B, Mikkola HKA, Miharada K, Bryder D, Larsson J, Magnusson M. Cell Reports. 2017 Dec 19;21(12):3514-3523. doi: 10.1016/j.celrep.2017.11.084.
https://pubmed.ncbi.nlm.nih.gov/29262330/
2016
LYVE1 marks the divergence of yolk sac definitive hemogenic endothelium from the primitive erythroid lineage.
Lee LK, Ghorbanian Y, Wang W, Wang Y, Kim YJ, Weissman IL, Inlay MA, Mikkola HKA. Cell Reports 2016 Nov 22;17(9):2286-2298. doi: 10.1016/j.celrep.2016.10.080.
https://pubmed.ncbi.nlm.nih.gov/27880904/
Differentiation of human embryonic stem cells to HOXA+ hemogenic vasculature that resembles the aorta-gonad-mesonephros.
Ng ES, Azzola L, Vlahos K Hirst C, Jokubaitis VJ, Yu QC, Bruveris FF, Calvanese V, Phipson B, Maksimovic J, Januar V, Zhang Z, Williams B, Conscience A, Durnall J, Jackson S, Costa M, Elliott D, Haylock D, Nilsson SK, Saffery R, Oshlack A, Mikkola HKA, Stanley EG, and Elefanty AG. Nature Biotechnology 2016 Nov;34(11):1168-1179. doi: 10.1038/nbt.3702. Epub 2016 Oct 17.
https://pubmed.ncbi.nlm.nih.gov/27748754/
MEF2C Protects Bone Marrow B Lymphoid Progenitors during Stress Hematopoiesis.
Wang W, Org T, Montel-Hagen A, Pioli P, Israely E, Duan D, Malkin D, Flach J, Schiestl R.H, Mikkola HKA.
Nat Commun. 2016 Aug 10;7:12376. doi: 10.1038/ncomms12376. PMID: 27507714
https://pubmed.ncbi.nlm.nih.gov/27507714/
Critical requirement of VEGF-C in transition to fetal erythropoiesis.
Fang S, Nurmi H, Heinolainen K, Chen S, Salminen E, Saharinen P, Mikkola HK, Alitalo K.
Blood. 2016 Jun 24. pii: blood-2015-12-687970. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.gov/27343251/
Medial HOXA genes demarcate haematopoietic stem cell fate during human development.
Dou DR, Calvanese V, Sierra MI, Nguyen AT, Minasian A, Saarikoski P, Sasidharan R, Ramirez CM, Zack JA, Crooks GM, Galic Z, Mikkola HK.
Nat Cell Biol. 2016 Jun;18(6):595-606. doi: 10.1038/ncb3354. Epub 2016 May 16.
https://pubmed.ncbi.nlm.nih.gov/27183470/
Tracking HSC Origin: From Bench to Placenta.
Calvanese V, Mikkola HK.
Dev Cell. 2016 Mar 7;36(5):479-80. doi: 10.1016/j.devcel.2016.02.022.
https://www.cell.com/developmental-cell/fulltext/S1534-5807(16)30077-6
2015
GLI2 inhibition abrogates human leukemia stem cell dormancy
Sadarangani A, Pineda G, Lennon KM, Chun HJ, Shih A, Schairer AE, Court AC, Goff DJ, Prashad SL, Geron I, Wall R, McPherson JD, Moore RA, Pu M, Bao L, Jackson-Fisher A, Munchhof M, VanArsdale T, Reya T, Morris SR, Minden MD, Messer K, Mikkola HK, Marra MA, Hudson TJ, Jamieson CH. J Transl Med. 2015 Mar 21;13:98. doi: 10.1186/s12967-015-0453-9.
http://www.ncbi.nlm.nih.gov/pubmed/25889765
Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence
Org T, Duan D, Ferrari R, Montel-Hagen A, Van Handel B, Kerenyi M, Sasidharan R, Fujiwara Y, Orkin S, Kurdistani SK, Mikkola HKA. EMBO J Epublication ahead of print Jan 2015. 34(6):759-77
http://www.ncbi.nlm.nih.gov/pubmed/25564442
Atlas of the Cellular and Molecular Development of Human Hematopoiesis
Van Handel B, Chhabra A, Mikkola HKA. Hematopoietic Niches, In, Dame, C., Fliedner, T.M., Sola-Visner, M., Yoder, M.C. (Eds.). 2015 Invited book chapter.
http://www.springer.com/us/book/9783642246777
GPI-80 Defines Self-renewal Ability in Hematopoietic Stem Cells during Human Development
Prashad SL, Calvanese V, Yao CY, Kaiser J, Sasidharan R, Crooks, G, Magnusson M, Mikkola HKA. Cell Stem Cell, 2015 Jan 8;16(1):80-7. doi: 10.1016/j.stem.2014.10.020. Epub 2014 Nov 13. PMID: 25465114
http://www.ncbi.nlm.nih.gov/pubmed/25465114
2014
The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis
Mishra BP, Zaffuto KM, Artinger EL, Org T, Mikkola HK, Cheng C, Djabali M, Ernst P. Cell Rep. 2014 May 22;7(4):1239-47. Epub 2014 May 9.
http://www.ncbi.nlm.nih.gov/pubmed/24813891
Sex hormone drives blood stem cell reproduction
Calvanese V, Lee LK, Mikkola HK. EMBO J. 2014 Mar 18;33(6) PMID:24562387. Invited News and Views
http://www.ncbi.nlm.nih.gov/pubmed/24562387
Progesterone Receptor in the Vascular Endothelium Triggers Physiological Uterine Permeability Pre-implantation
Goddard LM, Murphy TJ, Org T, Enciso JM, Hashimoto-Partyka MK, Warren CM, Domigan CK, McDonald AI, He H, Sanchez LA, Allen NC, Orsenigo F, Chao LC, Dejana E, Tontonoz P, Mikkola HK, Iruela-Arispe ML. Cell. 2014 Jan 30;156(3):549-62. doi: 10.1016/j.cell.2013.12.025. PMID: 24485460
http://www.ncbi.nlm.nih.gov/pubmed/24485460
2013
c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface
Ueno M, Lee LK, Chhabra A, Kim YJ, Sasidharan R, Van Handel B, Wang Y, Kamata M, Kamran P, Sereti K-J, Ardehali R, Jiang M, Mikkola HKA. Dev Cell 2013;Nov27(4):373-86.
http://www.ncbi.nlm.nih.gov/pubmed/24286824
In vivo mapping of Notch pathway activity in normal and stress hematopoiesis
Oh P, Lobry C, Gao J, Tikhonova A, Loizou E, Manet J, van Handel B, Ibrahim S, Greve J, Mikkola H, Artavanis-Tsakonas S, and Aifantis I. Cell Stem Cell, 2013 Jun 19. [Epub ahead of print]. 2013 Aug 1;13(2):256
http://www.ncbi.nlm.nih.gov/pubmed/23791481
Selective suppression of endothelial cytokine production by progesterone receptor
Goddard LM, Ton AN, Org T, Mikkola HK, Iruela-Arispe ML.Vascul Pharmacol. 2013 Jun 6. doi:pii: S1537 1891 (13)00074-8. \10.1016/j.vph.2013.06.001[Epub ahead of print]. Jul-Aug;59(1-2):36-43.
http://www.ncbi.nlm.nih.gov/pubmed/23747964
Hemogenic endocardium contributes to transient definitive hematopoiesis
Nakano H, Liu X, Arshi A, Nakashima Y, Van Handel Ben, Sasidharan R, Harmon AW, Shin J-H. Schwartz RJ, Conway S, Harvey RP, Pashmforoush M, Mikkola HKA, Nakano A. Nature Communications, 2013;4:1564. doi: 10.1038/ncomms2569.
http://www.ncbi.nlm.nih.gov/pubmed/23747964
Stem Cells in The Placenta
Rhodes Erikson KE, Chhabra A, Mikkola HKA. In Perinatal Stem Cell, Ed Kyle Cetrulo, 2013.
http://onlinelibrary.wiley.com/doi/10.1002/9780470480151.fmatter/pdf
Ex vivo expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised in vivo reconstitution ability
Magnusson M, Sierra MI. Sasidharan R, Prashad SL, Saarikoski P, Romero M, Van Handel B, Huang A, Li X, Mikkola HKA. PLOS One. 2013;8(1):e53912. doi: 10.1371/journal.pone.0053912. Epub 2013 Jan 16.
http://www.ncbi.nlm.nih.gov/pubmed/23342037
Nipah virus envelope pseudotyped lentiviruses efficiently target ephrinB2+ stem cell populations in vitro and bypass the liver sink when administered in vivo
Palomeros, K., Vigant, F., Van Handel, B., Pernet, O., Chikere, K., Hong, P., Sherman, S.P., Patterson, M., An, D.S., Lowry, W.E., Mikkola, H.K., Morizono, K., Pyle, A.D., and Lee, B., J Virol. 2013 Feb;87(4):2094-108. doi: 10.1128/JVI.02032-12.Epub 2012 Nov 28.
http://www.ncbi.nlm.nih.gov/pubmed/23192877
2012
Combinatorial Assembly of Developmental Stage-Specific Enhancers Controls Gene Expression Programs during Human Erythropoiesis
Xu J, Shao Z, Glass K, Bauer DE, Pinello L, Van Handel B, Hou S, Stamatoyannopoulos J.A, Mikkola HKA, Yuan G-C, Orkin SH. Dev Cell 2012 Oct 3. pii: S1534-5807
http://www.ncbi.nlm.nih.gov/pubmed/23041383
Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells
Nsair A, Schenke-Layland K, Van Handel B, Evseenko D, Kahn M, Zhao P, Mendelis J, Heydarkhan S, Awaji O, Vottler M, Geist S, Chyu J, Gago-Lopez N, Crooks GM, Plath K, Goldhaber J, Mikkola HK, Maclellan WR. PLoS One.2012;7(10):e45603. doi:10.1371/journal.pone.0045603. Epub 2012 Oct 9
http://www.ncbi.nlm.nih.gov/pubmed/23056209
Lymphoid Priming in Human Bone Marrow Begins Prior to CD10 Expression with Up-Regulation of L-selectin
Kohn LA, Hao Q-L, Sasidharan R, Parekh S, Ge S, Zhu J, Mikkola HKA, Crooks GM. Nature Immunol, Oct;13(10):963-71, 2012
http://www.ncbi.nlm.nih.gov/pubmed/22941246
Dynamic Distribution of Linker Histone H1.5 in Cellular Differentiation
Li J, Patterson M, Mikkola HKA, Lowry W, Kurdistani SK. Plos Genetics, 2012 Aug;82012.
http://www.ncbi.nlm.nih.gov/pubmed/22956909
Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium
Van Handel B*, Montel-Hagen A*, Sasidharan R, Ferrari R, Boorgeerd K, Nakano H, Org, T, Li X, Zhou J, Pellegrini M, Orkin SH, Nakano A, Kurdistani SK, Evans S, Mikkola HKA. Cell, 2012, Aug 3. 150:590-605
http://www.ncbi.nlm.nih.gov/pubmed/22863011
CCN2/Connective Tissue Growth Factor Is Essential for Pericyte Adhesion and Endothelial Basement Membrane Formation during Angiogenesis
Hall-Glenn F, De Young RA, Huang BL, van Handel B, Hofmann JJ, Chen TT, Choi A, Ong JR, Benya PD, Mikkola H, Iruela-Arispe ML, Lyons KM. PLoS One. 2012;7(2):e30562. Epub 2012 Feb 20.
http://www.ncbi.nlm.nih.gov/pubmed/22363445
Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling
Chhabra A, Lechner A, Acharya A, Ueno M, Van Handel B, Tallquist M, Mikkola HKA. Dev Cell, 2012 Mar 13;22(3):651-9
http://www.ncbi.nlm.nih.gov/pubmed/22387002
The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo
Hyde BB, Liesa M, Elorza AA, Qiu W, Haigh SE, Richey L, Mikkola HK, Schlaeger TM and Shirihai OS. Cell Death and Differentiation, 2012 Jan 13. doi: 10.1038/cdd.2011.195. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22240895
Coordinate regulation of neutrophil homeostasis by liver X receptors in mice
Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ. J. Clin Invest 2012, 122(1):337-47.
http://www.ncbi.nlm.nih.gov/pubmed/22156197
Defining the nature of human pluripotent progeny
Patterson M, Chan D, Ha I, Case D, Cui Y, Van Handel B, Mikkola HKA, and Lowry W. Cell Research, 2012 Jan;22(1):178-93
http://www.ncbi.nlm.nih.gov/pubmed/21844894
2011
Return to youth with Sox17
Chhabra, A., and Mikkola, H.K., Genes Dev, 25(15):1557 - 1562 (08/01/2011).
http://www.ncbi.nlm.nih.gov/pubmed/21828265
Recapitulation of the Embryonic Cardiovascular Progenitor Niche
Schenke-Layland K, Nsair, A, van Handel B, Angelis E, Gluck J, Vitteler M, Goldhaber J, Mikkola HKA, Kahn M, and MacLellan, R. Biomaterials, 2011 32:2748-56. Epub 2011 Jan 22
http://www.ncbi.nlm.nih.gov/pubmed/21257198
2010
Regulated expression of microRNAs-126/126* inhibit erythropoiesis from human embryonic stem cells
Huang, X, Gschweng, E, van Handel B, Cheng, D, Mikkola HKA and Witte, O. Blood, 117(7):2157 - 2165 (2011). Epub Dec 2010.
http://www.ncbi.nlm.nih.gov/pubmed/21163928
Hematopoietic stem cell development in the placenta
Gekas C, van Handel B, Chhabra A, Ueno M, and Mikkola HKA. International Journal for Developmental Biology. 2010 54:1089-1098. Invited review
http://www.ncbi.nlm.nih.gov/pubmed/20711986
First trimester human placenta is a site for terminal maturation of primitive erythroid cells
Van Handel B, Prashad S, Hassenzadeh-Kiabi N, Huang A, Atanassova B, Magnusson M, Chen A, Hamalainen E, Mikkola HKA. Blood 2010 Oct 28;116(17):3321-30. Epub 2010 Jul 13
http://www.ncbi.nlm.nih.gov/pubmed/20628147
Placenta as a novel source of hematopoietic stem cells
Lee L, Ueno M, Van Handel B and Mikkola HKA. Placenta as a novel source of hematopoietic stem cells. Current Opinion in Hematology. 2010 17:313-8.
http://www.ncbi.nlm.nih.gov/pubmed/20571394
Targeting leukemia stem cells
Mikkola HKA, Radu C, Witte ON. Nature Biotechnology. 2010, 3:237-8.
http://www.ncbi.nlm.nih.gov/pubmed/20212485
2009
Derivation of Primordial germ cells from Human Embryonic and Induced Pluripotent Stem Cells is significantly improved by co-culture with human fetal gonadal cells
Park TS, Galic Z, Conway AE, Lindgren A, Van Handel BJ. Magnusson M, Richter L, Teitell MA, Mikkola HKA, Lowry WE, Plath K, and Clark AT. Stem Cells, 2009. 27:783-95
http://www.ncbi.nlm.nih.gov/pubmed/19350678
Hematopoietic stem cell development in the placenta
Rhodes KE and Mikkola HKA. In Perinatal Stem Cells.
http://onlinelibrary.wiley.com/doi/10.1002/9780470480151.ch12/summary
DNA methylation is a guardian of stem cell self-renewal and multipotency
Gereige LM and Mikkola HKA. Nature Genetics, 2009 41:1164-6
http://www.ncbi.nlm.nih.gov/pubmed/19862008
LINKMEF2C is a lineage restricted target of SCL/tal1 and regulates megakaryopoiesis and B-cell homeostasis
Gekas C, Rhodes K, Gereige LM, Helgadottir HB, Ferrari R, Kurdistani SK, Montecino-Rodriquez E, Bassel-Duby RS, Olson EN, Orkin SH, Pellegrini M, Mikkola HKA. Blood, 2009. 113:3461-71 Prepublication online Feb 13th 2009.
http://www.ncbi.nlm.nih.gov/pubmed/19211936
ESAM: Adding to the hematopoietic toolbox
Mikkola H. Blood, 2009 113:2871-2872.
http://www.bloodjournal.org/content/113/13/2871
2008
Human Fetal Hemoglobin Expression is Regulated by the Developmental Stage-Specific Repressor BCL11A
Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HKA, Hirschhorn JN, Cantor AB, Orkin SH. Science, 2008, 322:1839
http://www.ncbi.nlm.nih.gov/pubmed/19056937
The ISSCR Junior Investigators Committee: Moving forward together
Mikkola H and de Haan, G. Cell Stem Cell 3:389-390. Invited committee forum article
http://www.cell.com/cell-stem-cell/abstract/S1934-5909(08)00479-7
Highlights from Philadelphia: ISSCR
De Bruijn M, Mikkola H, Snoeck WH, Keller G. Cell Stem Cell, 2008, 3:389-390. Invited meeting report
http://www.cell.com/cell-stem-cell/abstract/S1934-5909(08)00413-X
Isolation and visualization of hematopoietic stem cells in the placenta
Gekas C, Rhodes KE and Mikkola HKA. Curr Protoc Stem Cell Biol. 2008 Aug;Chapter 2:Unit 2A.8.1-2A.8.14 Invited protocol article
http://www.ncbi.nlm.nih.gov/pubmed/18729047
UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis
Elorza AA, Hyde BB, Mikkola HK, Collins S, Shirihai OS. J Biol Chem. 2008283:30461-70. Prepublication online Aug 7 2008.
http://www.ncbi.nlm.nih.gov/pubmed/18687678
Hematopoietic Stem Cells in Transit - Where’s the Niche?
Magnusson M and Mikkola HK. Cell Stem Cell 2008, 2:302.
http://www.ncbi.nlm.nih.gov/pubmed/18397748
Reprogrammed fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages
Schenke-Layland K, Rhodes K, Angelis E, Butylkova Y, Heydarkhan-Hagvall S, Gekas C, Zhang R, Goldhaber J, Mikkola HK, Plath K and MacLellan WR. Stem Cells 26:1537-46. 2008. May, 2008 prepublication online.
http://www.ncbi.nlm.nih.gov/pubmed/18450826
The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation
Rhodes KE, Gekas C, Wang Y, Lux C, Francis C, Hamalainen E, Orkin SH, Yoder M, Mikkola HKA. Cell Stem Cell, 2:252-263, 2008
http://www.ncbi.nlm.nih.gov/pubmed/18371450
2007
Collagen IV induces trophoectoderm differentiation of mouse embryonic stem cells
Schenke-Layland K, Angelis E, Rhodes K, Hagvall SH, Mikkola HKA and MacLellan WR. Stem Cells, 2007, 25:1529-38. Prepublication online March 2007.
http://www.ncbi.nlm.nih.gov/pubmed/17363553
The hematopoietic stem cell and its niche: A comparative view
Martinez-Agosto J, Mikkola HKA, Hartenstein V, Banerjee U. Genes Dev. 2007;21:3044-60.
http://www.ncbi.nlm.nih.gov/pubmed/18056420
2006
The journey of developing hematopoietic stem cells
Mikkola HKA and Orkin SH. Development, 2006, 133: 3733-3744.
http://www.ncbi.nlm.nih.gov/pubmed/16968814
Transcriptional activators, repressor and epigenetic modifiers controlling hematopoietic stem cell development
Teitell MA and Mikkola HKA. Pediatric Res, 2006;59:33R
http://www.ncbi.nlm.nih.gov/pubmed/16549546
2005
Placenta as a site for hematopoietic stem cell development
Mikkola HKA, Gekas C, Orkin SH and Dieterlen-Lievre F. Exp Hematol, 2005, 33:1048-54.
http://www.ncbi.nlm.nih.gov/pubmed/16140153
Placenta is a niche for hematopoietic stem cells
Gekas C, Dieterlen-Lievre F, Orkin SH and Mikkola HKA. Developmental Cell, 2005, 8:365-375. Prepublication online Feb 28, 2005.
http://www.ncbi.nlm.nih.gov/pubmed/15737932
Tie2Cre-mediated gene ablation defines the Stem Cell Leukemia gene (SCL/tal1)-dependent window during hematopoietic stem cell development
Schlaeger TM, Mikkola HKA, Gekas C, Helgadottir HB and Orkin SH. Blood, 2005, 5:3871-3874. Prepublication online Jan 27, 2005.
http://www.ncbi.nlm.nih.gov/pubmed/15677556
2004
Gene targeting and transgenic strategies for analysis of hematopoietic development in the mouse
Mikkola HKA and Orkin SH. In Baron M, editor, Methods on Molecular Medicine, 2004, 826:3-22.
http://www.ncbi.nlm.nih.gov/pubmed/15492385
Decoding Hematopoietic Specificity in the Helix-Loop-Helix Domain of the Transcription Factor SCL/Tal-1 Mol Cell Biol
Schlaeger TM, Schuh A, Flitter S, Fisher A, Mikkola H, Orkin SH, Vyas P and Porcher C. 2004;24:7491-7502
http://www.ncbi.nlm.nih.gov/pubmed/15314159
2003
Hematopoietic stem cells retain long term reconstitution activity and multipotency in the absence of the stem cell leukemia (SCL/tal1) gene
Mikkola HKA, Klintman J, Yang H, Hock H, Schlaeger TM, Fujiwara, Y and Orkin SH. Nature 2003;421:547-51.
http://www.ncbi.nlm.nih.gov/pubmed/12540851
CD41 expression marks the initiation of definitive hematopoiesis in the mouse embryo
Mikkola HKA, Fujiwara Y, Traver D, Schlaeger TM and Orkin SH. Blood 2003;101:508-16.
http://www.ncbi.nlm.nih.gov/pubmed/12393529
2002
The search for the hemangioblast
Mikkola HKA and Orkin SH. J Hematother Stem Cell Res 2002;11:9-17.
http://www.ncbi.nlm.nih.gov/pubmed/11847000
2001
Lentiviral-Mediated Gene Transfer into Hematopoietic Stem Cells
Woods N-B, Mikkola H, Nilsson E, Olsson K, Trono D and Karlsson S. J Intern Med. 2001;249:339-43.
http://www.ncbi.nlm.nih.gov/pubmed/11298854
2000
Lentivirus gene transfer in murine hematopoietic progenitor cells is compromised by a delay in proviral integration and results in transduction mosaicism and heterogeneous gene expression in progeny cells
Mikkola H, Woods NB, Sjogren M, Helgadottir H, Hamaguchi I, Jacobsen SE, Trono D and Karlsson S. J Virol 2000, 74:11911-11918.
http://www.ncbi.nlm.nih.gov/pubmed/11090191
Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells
Woods NB, Fahlman C, Mikkola H, Hamaguchi I, Olsson K, Zufferey R, Jacobsen SE, Trono D and Karlsson S.. Blood 2000;96:3725-33.
http://www.ncbi.nlm.nih.gov/pubmed/11090053
Lentiviral gene expression during ES cell derived hematopoietic development in vitro
Hamaguchi I, Panagopoulos I, Andersson E, Woods N-B, Fahlman C, Mikkola H, Carlsson L, Zufferey R, Trono D and Karlsson S. J Virol 2000;74:10778-84.
http://www.ncbi.nlm.nih.gov/pubmed/11044122
Structure and Function of Factor XIII
in Colman, Hirsh, Marder, Clowes, George, editors, Hemostasis and Thrombosis: Basic principles and Clinical Practise 2000, p 233-47
Loewy A, McDonagh J, Mikkola H, Teller D and Yee V.
Effect of Val 34 Leu polymorphism on the activation of the coagulation factor XIII-A
Wartiovaara U, Mikkola H, Szoke G, Haramura G, Karpati L, Balogh I, Lassila R, Muszbek L and Palotie A. Thromb Haemost. 2000;84:595-600.
http://www.ncbi.nlm.nih.gov/pubmed/11057856
Val 34 Leu polymorphism of plasma factor XIII: biochemistry and epidemiology in familial thrombophilia
Balogh I, Szoke G, Karpati L, Wartiovaara U, Katona E, Komaromi I, Haramura G, Pfliegler G, Mikkola H and Muszbek L. Blood. 2000;96:2479-86.
http://www.ncbi.nlm.nih.gov/pubmed/11001900
1999
Leu factor XIII polymorphism in inflammatory bowel disease
Heliö T, Wartiovaara U, Halme L, Turunen U-M, Mikkola H, Palotie A, Färkkilä M and Kontula K. Arg506->Gln factor V mutation and Val34->. Scand J Gastroent 1999;2:170-4.
http://www.ncbi.nlm.nih.gov/pubmed/10192195
Association of FXIII Val34Leu with decreased risk of myocardial infarction in Finnish males
Wartiovaara U, Perola M, Mikkola H, Tötterman K-J, Salonen V, Tikkanen M, Grant P, Vartiainen E, Karhunen P, Peltonen L and Palotie A. Atherosclerosis 1999;104:295-300.
http://www.ncbi.nlm.nih.gov/pubmed/10030380
1998
Peripheral platelets express VEGF and VEGF-C which are released during platelet activation
Wartiovaara U, Salven P, Mikkola H, Lassila R, Joukov V, Ristimäki A, Orpana A, Heikinheimo M, Joensuu H, Alitalo K and Palotie A. Thromb Haemost 1998;80:171-5.
http://www.ncbi.nlm.nih.gov/pubmed/9684805
Association of a common polymorphism in the factor XIII gene with myocardial infarction
Kohler H, Stickland M, Ossei-Gerning N, Carter A, Mikkola H and Grant P. Thromb Haemost 1998;79:8-13.
http://www.ncbi.nlm.nih.gov/pubmed/9459313
1997
Transglutaminase 1 mutations in autosomal recessive congenital icthyosis: private and recurrent mutations in an isolated population
Laiho E, Ignatius J, Mikkola H, Yee VC, Teller DC, Niemi K-M, Saarialho-Kere U, Kere J and Palotie A. Am J Hum Genet 1997;61:529-538.
http://www.ncbi.nlm.nih.gov/pubmed/9326318
Molecular mechanisms of mutations in FXIII deficiency: in vitro expression in COS-cells demonstrates intracellular degradation of the mutant proteins
Mikkola H, Muszbek L, Hämäläinen E, Haramura G, Jalanko A and Palotie A. Thromb Haemost 1997;78:1068-74.
http://www.ncbi.nlm.nih.gov/pubmed/9241733
Molecular mechanism of a mild phenotype in coagulation factor FXIII deficiency: a splicing mutation permitting partial correct splicing of FXIII A-subunit mRNA
Mikkola H, Muszbek L, Laiho E, Syrjälä M, Hämäläinen E, Haramura G, Salmi T, Peltonen L and Palotie A. Blood1997;88:1279-87.
http://www.ncbi.nlm.nih.gov/pubmed/9028951
1996
Novel aspects of blood coagulation factor XIII. Critical reviews in clinical laboratory sciences
Muszbek L, Adany R and Mikkola H. 1996;33:357-421.
http://www.ncbi.nlm.nih.gov/pubmed/8922891
Gene defects in factor XIII deficiency. Seminars in Thrombosis and Haemostasis
Mikkola H and Palotie A. 1996;22:393-8.
http://www.ncbi.nlm.nih.gov/pubmed/8989822
Four novel mutations in coagulation factor XIII deficiency: Consequences to expression and structure of the A-subunit
Mikkola H, Yee VC, Syrjälä M, Seitz R, Egbring R, Petrini P, Ljung R, Ingerslev J, Teller DC, Peltonen L and Palotie A. Blood 1996;87:141-51.
http://www.ncbi.nlm.nih.gov/pubmed/8547636
1994
Deficiency in the A-subunit of coagulation factor XIII: Two novel point mutations demonstrate different effects on transcript levels
Mikkola H, Syrjälä M, Rasi V, Vahtera E, Peltonen L and Palotie A. Blood 1994;84:517-25.
http://www.ncbi.nlm.nih.gov/pubmed/8025280
