Dou, Calvanese et al NCB 2016

Dou, Calvanese et al NCB 2016

Org, Duan et al. EMBO 2015

Org, Duan et al. EMBO 2015

Prashad et al. Cell Stem Cell 2015

Prashad et al. Cell Stem Cell 2015

Ueno et al. Developmental Cell 2013

Ueno et al. Developmental Cell 2013

Van Handel, Montel-Hagen Cell 2012

Van Handel, Montel-Hagen Cell 2012

Chhabra et al. Dev. Cell 2012

Chhabra et al. Dev. Cell 2012

Van Handel et al Blood 2010

Van Handel et al Blood 2010

Gekas et al. Blood 2009

Gekas et al. Blood 2009

Rhodes et al. Cell Stem Cell 2008

Rhodes et al. Cell Stem Cell 2008

Publications

2016

Critical requirement of VEGF-C in transition to fetal erythropoiesis.

Fang S, Nurmi H, Heinolainen K, Chen S, Salminen E, Saharinen P, Mikkola HK, Alitalo K.

Blood. 2016 Jun 24. pii: blood-2015-12-687970. [Epub ahead of print]

 

Medial HOXA genes demarcate haematopoietic stem cell fate during human development.

Dou DR, Calvanese V, Sierra MI, Nguyen AT, Minasian A, Saarikoski P, Sasidharan R, Ramirez CM, Zack JA, Crooks GM, Galic Z, Mikkola HK.

Nat Cell Biol. 2016 Jun;18(6):595-606. doi: 10.1038/ncb3354. Epub 2016 May 16.

Tracking HSC Origin: From Bench to Placenta.

Calvanese V, Mikkola HK.

Dev Cell. 2016 Mar 7;36(5):479-80. doi: 10.1016/j.devcel.2016.02.022.

2015
 
GLI2 inhibition abrogates human leukemia stem cell dormancy

Sadarangani A, Pineda G, Lennon KM, Chun HJ, Shih A, Schairer AE, Court AC, Goff DJ, Prashad SL, Geron I, Wall R, McPherson JD, Moore RA, Pu M, Bao L, Jackson-Fisher A, Munchhof M, VanArsdale T, Reya T, Morris SR, Minden MD, Messer K, Mikkola HK, Marra MA, Hudson TJ, Jamieson CH. J Transl Med. 2015 Mar 21;13:98. doi: 10.1186/s12967-015-0453-9.

http://www.ncbi.nlm.nih.gov/pubmed/25889765

Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence

Org T, Duan D, Ferrari R, Montel-Hagen A, Van Handel B, Kerenyi M, Sasidharan R, Fujiwara Y, Orkin S, Kurdistani SK, Mikkola HKA. EMBO J Epublication ahead of print Jan 2015. 34(6):759-77

http://www.ncbi.nlm.nih.gov/pubmed/25564442

 

Atlas of the Cellular and Molecular Development of Human Hematopoiesis

Van Handel B, Chhabra A, Mikkola HKA. Hematopoietic Niches, In, Dame, C., Fliedner, T.M., Sola-Visner, M., Yoder, M.C. (Eds.). 2015 Invited book chapter. 

http://www.springer.com/us/book/9783642246777

GPI-80 Defines Self-renewal Ability in Hematopoietic Stem Cells during Human Development

Prashad SL, Calvanese V, Yao CY, Kaiser J, Sasidharan R, Crooks, G, Magnusson M, Mikkola HKA. Cell Stem Cell, 2015 Jan 8;16(1):80-7. doi: 10.1016/j.stem.2014.10.020. Epub 2014 Nov 13. PMID: 25465114

http://www.ncbi.nlm.nih.gov/pubmed/25465114

2014 

The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis

Mishra BP, Zaffuto KM, Artinger EL, Org T, Mikkola HK, Cheng C, Djabali M, Ernst P. Cell Rep. 2014 May 22;7(4):1239-47. Epub 2014 May 9.

http://www.ncbi.nlm.nih.gov/pubmed/24813891

 

Sex hormone drives blood stem cell reproduction

Calvanese V, Lee LK, Mikkola HK. EMBO J. 2014 Mar 18;33(6) PMID:24562387. Invited News and Views

http://www.ncbi.nlm.nih.gov/pubmed/24562387

 

Progesterone Receptor in the Vascular Endothelium Triggers Physiological Uterine Permeability Pre-implantation

Goddard LM, Murphy TJ, Org T, Enciso JM, Hashimoto-Partyka MK, Warren CM, Domigan CK, McDonald AI, He H, Sanchez LA, Allen NC, Orsenigo F, Chao LC, Dejana E, Tontonoz P, Mikkola HK, Iruela-Arispe ML. Cell. 2014 Jan 30;156(3):549-62. doi: 10.1016/j.cell.2013.12.025. PMID: 24485460

http://www.ncbi.nlm.nih.gov/pubmed/24485460

 

2013
 
c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface

Ueno M, Lee LK, Chhabra A, Kim YJ, Sasidharan R, Van Handel B, Wang Y, Kamata M, Kamran P, Sereti K-J, Ardehali R, Jiang M, Mikkola HKA. Dev Cell 2013;Nov27(4):373-86. 

http://www.ncbi.nlm.nih.gov/pubmed/24286824

 

In vivo mapping of Notch pathway activity in normal and stress hematopoiesis

Oh P, Lobry C, Gao J, Tikhonova A, Loizou E, Manet J, van Handel B, Ibrahim S, Greve J, Mikkola H, Artavanis-Tsakonas S, and Aifantis I. Cell Stem Cell, 2013 Jun 19. [Epub ahead of print]. 2013 Aug 1;13(2):256

http://www.ncbi.nlm.nih.gov/pubmed/23791481

 

Selective suppression of endothelial cytokine production by progesterone receptor 

Goddard LM, Ton AN, Org T, Mikkola HK, Iruela-Arispe ML.Vascul Pharmacol. 2013 Jun 6. doi:pii: S1537 1891 (13)00074-8. \10.1016/j.vph.2013.06.001[Epub ahead of print]. Jul-Aug;59(1-2):36-43.

http://www.ncbi.nlm.nih.gov/pubmed/23747964

 

Hemogenic endocardium contributes to transient definitive hematopoiesis

Nakano H, Liu X, Arshi A, Nakashima Y, Van Handel Ben, Sasidharan R, Harmon AW, Shin J-H. Schwartz RJ, Conway S, Harvey RP, Pashmforoush M, Mikkola HKA, Nakano A. Nature Communications, 2013;4:1564. doi: 10.1038/ncomms2569.

http://www.ncbi.nlm.nih.gov/pubmed/23747964

 

Stem Cells in The Placenta

Rhodes Erikson KE, Chhabra A, Mikkola HKA. In Perinatal Stem Cell, Ed Kyle Cetrulo, 2013

http://onlinelibrary.wiley.com/doi/10.1002/9780470480151.fmatter/pdf

 

Ex vivo expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised in vivo reconstitution ability

Magnusson M, Sierra MI. Sasidharan R, Prashad SL, Saarikoski P, Romero M, Van Handel B, Huang A, Li X, Mikkola HKA. PLOS One. 2013;8(1):e53912. doi: 10.1371/journal.pone.0053912. Epub 2013 Jan 16.

http://www.ncbi.nlm.nih.gov/pubmed/23342037

 

Nipah virus envelope pseudotyped lentiviruses efficiently target ephrinB2+ stem cell populations in vitro and bypass the liver sink when administered in vivo

Palomeros, K., Vigant, F., Van Handel, B., Pernet, O., Chikere, K., Hong, P., Sherman, S.P., Patterson, M., An, D.S., Lowry, W.E., Mikkola, H.K., Morizono, K., Pyle, A.D., and Lee, B., J Virol. 2013 Feb;87(4):2094-108. doi: 10.1128/JVI.02032-12.Epub 2012 Nov 28.

http://www.ncbi.nlm.nih.gov/pubmed/23192877

 

2012

Combinatorial Assembly of Developmental Stage-Specific Enhancers Controls Gene Expression Programs during Human Erythropoiesis

Xu J, Shao Z, Glass K, Bauer DE, Pinello L, Van Handel B, Hou S, Stamatoyannopoulos J.A, Mikkola HKA, Yuan G-C, Orkin SH. Dev Cell 2012 Oct 3. pii: S1534-5807

http://www.ncbi.nlm.nih.gov/pubmed/23041383

 

Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells

Nsair A, Schenke-Layland K, Van Handel B, Evseenko D, Kahn M, Zhao P, Mendelis J, Heydarkhan S, Awaji O, Vottler M, Geist S, Chyu J, Gago-Lopez N, Crooks GM, Plath K, Goldhaber J, Mikkola HK, Maclellan WR. PLoS One.2012;7(10):e45603. doi:10.1371/journal.pone.0045603. Epub 2012 Oct 9

http://www.ncbi.nlm.nih.gov/pubmed/23056209

 

Lymphoid Priming in Human Bone Marrow Begins Prior to CD10 Expression with Up-Regulation of L-selectin

Kohn LA, Hao Q-L, Sasidharan R, Parekh S, Ge S, Zhu J, Mikkola HKA, Crooks GM. Nature Immunol, Oct;13(10):963-71, 2012

http://www.ncbi.nlm.nih.gov/pubmed/22941246

 

Dynamic Distribution of Linker Histone H1.5 in Cellular Differentiation

Li J, Patterson M, Mikkola HKA, Lowry W, Kurdistani SK. Plos Genetics, 2012 Aug;82012.

http://www.ncbi.nlm.nih.gov/pubmed/22956909

 

Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium

Van Handel B*, Montel-Hagen A*, Sasidharan R, Ferrari R, Boorgeerd K, Nakano H, Org, T, Li X, Zhou J, Pellegrini M, Orkin SH, Nakano A, Kurdistani SK, Evans S, Mikkola HKA. Cell, 2012, Aug 3. 150:590-605

http://www.ncbi.nlm.nih.gov/pubmed/22863011

 

CCN2/Connective Tissue Growth Factor Is Essential for Pericyte Adhesion and Endothelial Basement Membrane Formation during Angiogenesis

Hall-Glenn F, De Young RA, Huang BL, van Handel B, Hofmann JJ, Chen TT, Choi A, Ong JR, Benya PD, Mikkola H, Iruela-Arispe ML, Lyons KM. PLoS One. 2012;7(2):e30562. Epub 2012 Feb 20.

http://www.ncbi.nlm.nih.gov/pubmed/22363445

 

Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling

Chhabra A, Lechner A, Acharya A, Ueno M, Van Handel B, Tallquist M, Mikkola HKA. Dev Cell, 2012 Mar 13;22(3):651-9

http://www.ncbi.nlm.nih.gov/pubmed/22387002

 

The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo

Hyde BB, Liesa M, Elorza AA, Qiu W, Haigh SE, Richey L, Mikkola HK, Schlaeger TM and Shirihai OS. Cell Death and Differentiation, 2012 Jan 13. doi: 10.1038/cdd.2011.195. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/22240895

 

Coordinate regulation of neutrophil homeostasis by liver X receptors in mice

Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ. J. Clin Invest 2012, 122(1):337-47

http://www.ncbi.nlm.nih.gov/pubmed/22156197

 

Defining the nature of human pluripotent progeny

Patterson M, Chan D, Ha I, Case D, Cui Y, Van Handel B, Mikkola HKA, and Lowry W. Cell Research, 2012 Jan;22(1):178-93

http://www.ncbi.nlm.nih.gov/pubmed/21844894

 

2011

Return to youth with Sox17

Chhabra, A., and Mikkola, H.K., Genes Dev, 25(15):1557 - 1562 (08/01/2011). 

http://www.ncbi.nlm.nih.gov/pubmed/21828265

 

Recapitulation of the Embryonic Cardiovascular Progenitor Niche

Schenke-Layland K, Nsair, A, van Handel B, Angelis E, Gluck J, Vitteler M, Goldhaber J, Mikkola HKA, Kahn M, and MacLellan, R. Biomaterials, 2011 32:2748-56. Epub 2011 Jan 22

http://www.ncbi.nlm.nih.gov/pubmed/21257198

 

2010
 
Regulated expression of microRNAs-126/126* inhibit erythropoiesis from human embryonic stem cells

Huang, X, Gschweng, E, van Handel B, Cheng, D, Mikkola HKA and Witte, O. Blood, 117(7):2157 - 2165 (2011). Epub Dec 2010.

http://www.ncbi.nlm.nih.gov/pubmed/21163928

 

Hematopoietic stem cell development in the placenta

Gekas C, van Handel B, Chhabra A, Ueno M, and Mikkola HKA. International Journal for Developmental Biology. 2010 54:1089-1098. Invited review

http://www.ncbi.nlm.nih.gov/pubmed/20711986

 

First trimester human placenta is a site for terminal maturation of primitive erythroid cells

Van Handel B, Prashad S, Hassenzadeh-Kiabi N, Huang A, Atanassova B, Magnusson M, Chen A, Hamalainen E, Mikkola HKA. Blood 2010 Oct 28;116(17):3321-30. Epub 2010 Jul 13

http://www.ncbi.nlm.nih.gov/pubmed/20628147

 

Placenta as a novel source of hematopoietic stem cells

Lee L, Ueno M, Van Handel B and Mikkola HKA. Placenta as a novel source of hematopoietic stem cells. Current Opinion in Hematology. 2010 17:313-8. 

http://www.ncbi.nlm.nih.gov/pubmed/20571394

 

Targeting leukemia stem cells

Mikkola HKA, Radu C, Witte ON. Nature Biotechnology. 2010, 3:237-8. 

http://www.ncbi.nlm.nih.gov/pubmed/20212485

 

2009

Derivation of Primordial germ cells from Human  Embryonic and Induced Pluripotent Stem Cells is significantly improved by co-culture with human fetal gonadal cells

Park TS, Galic Z, Conway AE, Lindgren A, Van Handel BJ. Magnusson M, Richter L, Teitell MA, Mikkola HKA, Lowry WE, Plath K, and Clark AT. Stem Cells, 2009. 27:783-95

http://www.ncbi.nlm.nih.gov/pubmed/19350678

 

Hematopoietic stem cell development in the placenta

Rhodes KE and Mikkola HKA. In Perinatal Stem Cells.

http://onlinelibrary.wiley.com/doi/10.1002/9780470480151.ch12/summary

 

DNA methylation is a guardian of stem cell self-renewal and multipotency

Gereige LM and  Mikkola HKA. Nature Genetics, 2009  41:1164-6 

http://www.ncbi.nlm.nih.gov/pubmed/19862008

 

LINKMEF2C is a lineage restricted target of SCL/tal1 and regulates megakaryopoiesis and B-cell homeostasis

Gekas C, Rhodes K, Gereige LM, Helgadottir HB, Ferrari R, Kurdistani SK, Montecino-Rodriquez E, Bassel-Duby RS, Olson EN, Orkin SH, Pellegrini M, Mikkola HKA. Blood, 2009. 113:3461-71 Prepublication online Feb 13th 2009.

http://www.ncbi.nlm.nih.gov/pubmed/19211936

 

ESAM:  Adding to the hematopoietic toolbox

Mikkola H.  Blood, 2009 113:2871-2872.

http://www.bloodjournal.org/content/113/13/2871

 

2008

Human Fetal Hemoglobin Expression is Regulated by the Developmental Stage-Specific Repressor BCL11A

Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HKA, Hirschhorn JN, Cantor AB, Orkin SH. Science, 2008, 322:1839

http://www.ncbi.nlm.nih.gov/pubmed/19056937

 

The ISSCR Junior Investigators Committee: Moving forward together

Mikkola H and de Haan, G. Cell Stem Cell 3:389-390. Invited committee forum article

http://www.cell.com/cell-stem-cell/abstract/S1934-5909(08)00479-7

 

Highlights from Philadelphia: ISSCR

De Bruijn M, Mikkola H, Snoeck WH, Keller G. Cell Stem Cell, 2008, 3:389-390. Invited meeting report

http://www.cell.com/cell-stem-cell/abstract/S1934-5909(08)00413-X

 

Isolation and visualization of hematopoietic stem cells in the placenta

Gekas C, Rhodes KE and Mikkola HKA. Curr Protoc Stem Cell Biol. 2008 Aug;Chapter 2:Unit 2A.8.1-2A.8.14 Invited protocol article

http://www.ncbi.nlm.nih.gov/pubmed/18729047

 

UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis

Elorza AA, Hyde BB, Mikkola HK, Collins S, Shirihai OS.  J Biol Chem. 2008283:30461-70. Prepublication online  Aug 7 2008.

http://www.ncbi.nlm.nih.gov/pubmed/18687678

 

Hematopoietic Stem Cells in Transit - Where’s the Niche?

Magnusson M and Mikkola HK. Cell Stem Cell 2008, 2:302.

http://www.ncbi.nlm.nih.gov/pubmed/18397748

 

Reprogrammed fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages

Schenke-Layland K, Rhodes K, Angelis E, Butylkova Y, Heydarkhan-Hagvall S, Gekas C, Zhang R, Goldhaber J, Mikkola HK, Plath K and MacLellan WR. Stem Cells 26:1537-46. 2008. May, 2008 prepublication online. 

http://www.ncbi.nlm.nih.gov/pubmed/18450826

 

The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation

Rhodes KE, Gekas C, Wang Y, Lux C, Francis C, Hamalainen E, Orkin SH, Yoder M, Mikkola HKA. Cell Stem Cell, 2:252-263, 2008 

http://www.ncbi.nlm.nih.gov/pubmed/18371450

 

2007
 
Collagen IV induces trophoectoderm differentiation of mouse embryonic stem cells

Schenke-Layland K, Angelis E, Rhodes K, Hagvall SH, Mikkola HKA and MacLellan WR. Stem Cells, 2007, 25:1529-38. Prepublication online March 2007. 

http://www.ncbi.nlm.nih.gov/pubmed/17363553

 

The hematopoietic stem cell and its niche: A comparative view

Martinez-Agosto J, Mikkola HKA, Hartenstein V, Banerjee U. Genes Dev. 2007;21:3044-60. 

http://www.ncbi.nlm.nih.gov/pubmed/18056420

 

2006

The journey of developing hematopoietic stem cells

Mikkola HKA and Orkin SH. Development, 2006, 133: 3733-3744. 

http://www.ncbi.nlm.nih.gov/pubmed/16968814

 

Transcriptional activators, repressor and epigenetic modifiers  controlling hematopoietic stem cell development

Teitell MA and Mikkola HKA. Pediatric Res, 2006;59:33R

http://www.ncbi.nlm.nih.gov/pubmed/16549546

 

2005

Placenta as a site for hematopoietic stem cell development

Mikkola HKA, Gekas C, Orkin SH and Dieterlen-Lievre F. Exp Hematol, 2005, 33:1048-54.

http://www.ncbi.nlm.nih.gov/pubmed/16140153

 

Placenta is a niche for hematopoietic stem cells

Gekas C, Dieterlen-Lievre F, Orkin SH and Mikkola HKA. Developmental Cell, 2005, 8:365-375. Prepublication online Feb 28, 2005. 

http://www.ncbi.nlm.nih.gov/pubmed/15737932

 

Tie2Cre-mediated gene ablation defines the Stem Cell Leukemia gene (SCL/tal1)-dependent window during hematopoietic stem cell development

Schlaeger TM, Mikkola HKA, Gekas C, Helgadottir HB and Orkin SH. Blood, 2005, 5:3871-3874. Prepublication online Jan 27, 2005.

http://www.ncbi.nlm.nih.gov/pubmed/15677556

 

2004
 
Gene targeting and transgenic strategies for analysis of hematopoietic development in the mouse

Mikkola HKA and Orkin SH. In Baron M, editor, Methods on Molecular Medicine, 2004, 826:3-22. 

http://www.ncbi.nlm.nih.gov/pubmed/15492385

 

Decoding Hematopoietic Specificity in the Helix-Loop-Helix Domain of the Transcription Factor SCL/Tal-1 Mol Cell Biol

Schlaeger TM, Schuh A, Flitter S, Fisher A, Mikkola H, Orkin SH, Vyas P and Porcher C. 2004;24:7491-7502

http://www.ncbi.nlm.nih.gov/pubmed/15314159

 

2003

Hematopoietic stem cells retain long term reconstitution activity and multipotency in the absence of the stem cell leukemia (SCL/tal1) gene

Mikkola HKA, Klintman J, Yang H, Hock H, Schlaeger TM, Fujiwara, Y and Orkin SH. Nature 2003;421:547-51.

http://www.ncbi.nlm.nih.gov/pubmed/12540851

CD41 expression marks the initiation of definitive hematopoiesis in the mouse embryo

Mikkola HKA, Fujiwara Y, Traver D, Schlaeger TM and Orkin SH. Blood 2003;101:508-16.

http://www.ncbi.nlm.nih.gov/pubmed/12393529

 

2002

The search for the hemangioblast

Mikkola HKA and Orkin SH. J Hematother Stem Cell Res 2002;11:9-17. 

http://www.ncbi.nlm.nih.gov/pubmed/11847000

 

2001

Lentiviral-Mediated Gene Transfer into Hematopoietic Stem Cells

Woods N-B, Mikkola H, Nilsson E, Olsson K, Trono D and Karlsson S. J Intern Med. 2001;249:339-43. 

http://www.ncbi.nlm.nih.gov/pubmed/11298854

 

2000
 
Lentivirus gene transfer in murine hematopoietic progenitor cells is compromised by a delay in proviral integration and results in transduction mosaicism and heterogeneous gene expression in progeny cells

Mikkola H, Woods NB, Sjogren M, Helgadottir H, Hamaguchi I, Jacobsen SE, Trono D and Karlsson S.  J Virol 2000, 74:11911-11918.

http://www.ncbi.nlm.nih.gov/pubmed/11090191

 

Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells

Woods NB, Fahlman C, Mikkola H, Hamaguchi I, Olsson K, Zufferey R, Jacobsen SE, Trono D and Karlsson S.. Blood 2000;96:3725-33.

http://www.ncbi.nlm.nih.gov/pubmed/11090053

 

Lentiviral gene expression during ES cell derived hematopoietic development in vitro

Hamaguchi I, Panagopoulos I, Andersson E, Woods N-B, Fahlman C, Mikkola H, Carlsson L, Zufferey R, Trono D and Karlsson S. J Virol 2000;74:10778-84.

http://www.ncbi.nlm.nih.gov/pubmed/11044122

Structure and Function of Factor XIII 

in Colman, Hirsh, Marder, Clowes, George, editors, Hemostasis and Thrombosis: Basic principles and Clinical Practise 2000, p 233-47

Loewy A, McDonagh J, Mikkola H, Teller D and Yee V. 

 
Effect of Val 34 Leu polymorphism on the activation of the coagulation factor XIII-A

Wartiovaara U, Mikkola H, Szoke G, Haramura G, Karpati L, Balogh I, Lassila R, Muszbek L and Palotie A. Thromb Haemost. 2000;84:595-600.

http://www.ncbi.nlm.nih.gov/pubmed/11057856

 

Val 34 Leu polymorphism of plasma factor XIII: biochemistry and epidemiology in familial thrombophilia

Balogh I, Szoke G, Karpati L, Wartiovaara U, Katona E, Komaromi I, Haramura G, Pfliegler G, Mikkola H and Muszbek L. Blood. 2000;96:2479-86.

http://www.ncbi.nlm.nih.gov/pubmed/11001900

 

1999

Leu factor XIII polymorphism in inflammatory bowel disease

Heliö T, Wartiovaara U, Halme L, Turunen U-M, Mikkola H, Palotie A, Färkkilä M and Kontula K. Arg506->Gln factor V mutation and Val34->. Scand J Gastroent 1999;2:170-4.

http://www.ncbi.nlm.nih.gov/pubmed/10192195

Association of FXIII Val34Leu with decreased risk of myocardial infarction in Finnish males

Wartiovaara U, Perola M, Mikkola H, Tötterman K-J, Salonen V, Tikkanen M, Grant P, Vartiainen E, Karhunen P, Peltonen L and Palotie A. Atherosclerosis 1999;104:295-300.

http://www.ncbi.nlm.nih.gov/pubmed/10030380

 

1998

Peripheral platelets express VEGF and VEGF-C which are released during platelet activation

Wartiovaara U, Salven P, Mikkola H, Lassila R, Joukov V, Ristimäki A, Orpana A, Heikinheimo M, Joensuu H, Alitalo K and Palotie A. Thromb Haemost 1998;80:171-5.

http://www.ncbi.nlm.nih.gov/pubmed/9684805

 

Association of a common polymorphism in the factor XIII gene with myocardial infarction

Kohler H, Stickland M, Ossei-Gerning N, Carter A, Mikkola H and Grant P. Thromb Haemost 1998;79:8-13.

http://www.ncbi.nlm.nih.gov/pubmed/9459313

 

1997
 
Transglutaminase 1 mutations in autosomal recessive congenital icthyosis: private and recurrent mutations in an isolated population

Laiho E, Ignatius J, Mikkola H, Yee VC, Teller DC, Niemi K-M, Saarialho-Kere U, Kere J and Palotie A. Am J Hum Genet 1997;61:529-538.

http://www.ncbi.nlm.nih.gov/pubmed/9326318

 

Molecular mechanisms of mutations in FXIII deficiency: in vitro expression in COS-cells demonstrates intracellular degradation of the mutant proteins

Mikkola H, Muszbek L, Hämäläinen E, Haramura G, Jalanko A and Palotie A. Thromb Haemost 1997;78:1068-74.

http://www.ncbi.nlm.nih.gov/pubmed/9241733

 

Molecular mechanism of a mild phenotype in coagulation factor FXIII deficiency: a splicing mutation permitting partial correct splicing of FXIII A-subunit mRNA

Mikkola H, Muszbek L, Laiho E, Syrjälä M, Hämäläinen E, Haramura G, Salmi T, Peltonen L and Palotie A. Blood1997;88:1279-87.

http://www.ncbi.nlm.nih.gov/pubmed/9028951

 

1996

Novel aspects of blood coagulation factor XIII. Critical reviews in clinical laboratory sciences

Muszbek L, Adany R and Mikkola H. 1996;33:357-421. 

http://www.ncbi.nlm.nih.gov/pubmed/8922891

 

Gene defects in factor XIII deficiency. Seminars in Thrombosis and Haemostasis

Mikkola H and Palotie A. 1996;22:393-8. 

http://www.ncbi.nlm.nih.gov/pubmed/8989822

 

Four novel mutations in coagulation factor XIII deficiency: Consequences to expression and structure of the A-subunit

Mikkola H, Yee VC, Syrjälä M, Seitz R, Egbring R, Petrini P, Ljung R, Ingerslev J, Teller DC, Peltonen L and Palotie A. Blood 1996;87:141-51.

http://www.ncbi.nlm.nih.gov/pubmed/8547636

 

1994

Deficiency in the A-subunit of coagulation factor XIII: Two novel point mutations demonstrate different effects on transcript levels

Mikkola H, Syrjälä M, Rasi V, Vahtera E, Peltonen L and Palotie A. Blood 1994;84:517-25.

http://www.ncbi.nlm.nih.gov/pubmed/8025280